severe active ulcerative colitis and resistance to intravenous hydrocortisone therapy: successful treatment with methylprednisolone pulse therapy

Gene Expression Changes Associated with Resistance to Intravenous Corticosteroid Therapy in Children with Severe Ulcerative Colitis

BACKGROUND AND AIMS Microarray analysis of RNA expression allows gross examination of pathways operative in inflammation. We aimed to determine whether genes expressed in whole blood early following initiation of intravenous corticosteroid treatment can be associated with response. METHODS From a prospectively accrued cohort of 128 pediatric patients hospitalized for intravenous corticosteroi...

Methylprednisolone pulse therapy and intravenous cyclophosphamide therapy combined with cocktail therapy in severe pediatric Henoch-Schönlein purpura nephritis patient

Henoch-Schönlein purpura (HSP) is a common self-limited vasculitis in children. The long-term prognosis depends on renal involvement. In severe Henoch-Schönlein purpura nephritis (HSPN) patients, >50 % have crescent formation and nephrotic syndrome that are important predicted outcomes. Therefore, for such patients, an aggressive immunosuppressive therapy is needed to prevent the progression. H...

Reversal of renal allograft rejection with intravenous methylprednisolone "pulse" therapy.

REJECTION CONTINUES TO BE A MAJOR PROBLEM confronting the transplant recipient and his surgeon. Acute reject,ion of renal allografts is commonly treated by increasing the daily oral dose of corticosteraids. Multiple complications of this therapy, including gastrointestinal hemorrhage and increased susceptibility to infection, have been reported. Intermittent large-dose intravenous corticosteroi...

comparison of oral prednisolone pulse therapy with intravenous methyl prednisolone pulse therapy in severe alopecia areata

Hyperbaric oxygen therapy for severe ulcerative colitis.

Hyperbaric oxygen therapy has been used to successfully treat perineal Crohn's disease. We describe the first successful use of hyperbaric oxygen therapy in the treatment of ulcerative colitis, refractory to conventional therapies. Therapy consisted of 30 courses of 100% oxygen at a pressure of 2.0 atm absolute. Clinical remission was achieved on the basis of the Truelove-Witts and disease acti...

Medical Therapy of Active Ulcerative Colitis

BACKGROUND Medical therapy of mild and moderate ulcerative colitis (UC) of any extent is evidence-based and standardized by national and international guidelines. However, patients with steroid-refractory UC still represent a challenge. METHODS A literature search using PubMed (search terms: ulcerative colitis, therapy, new, 1-2008-2015) resulted in 821 publications. For the current article, ...